Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Fyn |
| Gene Name: | FYN |
| Protein Full Name: | Tyrosine-protein kinase Fyn |
| Alias: | EC 2.7.10.2; FYN; FYN oncogene related to SRC, FGR, YES; Kinase Fyn; MGC45350; P59-FYN; P59-Fyn; SLK; SYN |
| Mass (Da): | 60762 |
| Number AA: | 537 |
| UniProt ID: | P06241; B3KPS6; E1P556; Q5R3A8 |
| Locus ID: | 2534 |
| COSMIC ID: | FYN |
| Gene location on chromosome: | 6q21 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20681 |
| Percent of cancer specimens with mutations: | 0.54 |
| Normal role description: | FYN is a protein-tyrosine kinase that is implicated in the regulation of cell growth; it is associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. It activates pro-growth pathways. |
| Commentary on involvement of protein in cancer: | Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Phosphorylates RUNX3 |