Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTMA |
| Gene Name: | PTMA |
| Protein Full Name: | Prothymosin alpha |
| Alias: | gene sequence 28; prothymosin alpha; prothymosin, alpha; TMSA |
| Mass (Da): | 12070 |
| Number AA: | 110 |
| UniProt ID: | P06454 |
| Locus ID: | 5757 |
| COSMIC ID: | PTMA |
| Gene location on chromosome: | 2q37.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.11 |
| Normal role description: | PTMA is in many funtions within the cell. It regulations gene transcription of cellular and viral genes, chromatin remodeling, regulates cell proliferation, inhibits apoptosis and induces T cell responses. Overexpression in cancer increases cell proliferation and provides resistance to apoptosis. |