Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ENO1 |
| Gene Name: | ENO1 |
| Protein Full Name: | Alpha-enolase |
| Alias: | 2-phospho-D-glycerate hydro-lyase; Alpha enolase; EC 4.2.1.11; ENO-1; ENO1L1; ENO1P; ENOA; Enolase; Enolase, alpha; NNE; Non-neural enolase; Phosphopyruvate hydratase |
| Mass (Da): | 47169 |
| Number AA: | 434 |
| UniProt ID: | P06733 |
| Locus ID: | 2023 |
| COSMIC ID: | ENO1 |
| Gene location on chromosome: | 1p36.23 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.32 |
| Found in amplified chromosomal regions in human cancers: | Squamous cell lung carcinoma. |
| Normal role description: | ENO1 is a multifunctional enzyme that is involved in glycolysis and various other processes such as growth control, tolerance to hypoxia and allergic responses by stimulating immunoglobulin production. It may serve as a receptor and activator of plasminogen on the cell surface of for example leukocytes and neurons. The gene is upregulated in numerous cancer, but alternative splicing of the gene resulting in a shorter isoform (MBP-1) located in the nucleus, has been shown to bind to the c-Myc promoter and function as a tumour suppressor. |
| Commentary on involvement of protein in cancer: | 25% (1/4) of upper aerodigestive tract samples (pharynx) were also mutated (mis-sense), and so was 1/101 kidney- and 1/468 CNS samples. Only 2 ovarian samples were included (Sanger COSMIC). The chromosome section where the gene is located is often deleted in human malignancies, including neuroblastoma, melanoma, pheochromocytoma, breast, liver and colon cancer. |