Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TPM3 |
| Gene Name: | TPM3 |
| Protein Full Name: | Tropomyosin alpha-3 chain |
| Alias: | NEM1; TPM5; TPM-5; TRK; Tropomyosin 3; Tropomyosin alpha 3 chain; Tropomyosin gamma; Tropomyosin-3 |
| Mass (Da): | 32819 |
| Number AA: | 284 |
| UniProt ID: | P06753 |
| Locus ID: | 7170 |
| COSMIC ID: | TPM3 |
| Gene location on chromosome: | 1q21 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20717 |
| Percent of cancer specimens with mutations: | 0.16 |
| Deregulated in translocations: | t(1;2)(q25;p23) in ALCL and Inflammatory myofibroblastic tumors; 5' CLTC - 3' ALK (TPM3-ALK is contitutively activated); chromosome 1q inversions have shown to produce a TPM3-NTRK1 hybrid gene in a very few cases of papillary thyroid carcinoma. |
| Normal role description: | An immediate early gene. Involved in actin filament interaction. Gene defects linked to hereditary myopathies. Oncogenesis involving this gene is mediated by translocations causing constiuently activated oncoproteins such as ALK. Role in oncogenesis may be less clear for this gene in its native form |