Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PSAP |
| Gene Name: | PSAP |
| Protein Full Name: | Proactivator polypeptide |
| Alias: | Protein A;Cerebroside sulfate activator;Dispersin;Sphingolipid activator protein 1;Sulfatide/GM1 activator;A1 activator;Co-beta-glucosidase;Glucosylceramidase activator;Sphingolipid activator protein 2;Component C |
| Mass (Da): | 58113 |
| Number AA: | 524 |
| UniProt ID: | P07602 |
| Locus ID: | 5660 |
| COSMIC ID: | PSAP |
| Gene location on chromosome: | 10q22.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.41 |
| Normal role description: | PSAP has two forms and each form has a different funtion. The membrane bound form is involve in sphingolipid degradation. The secreted form is involved in growth, development and maintanence of peripheral and central nervous system by inducing processes such as apoptosis and activation of AKT/MAPK signalling pathway. Overexpression is correlated with increasing cancer progression but function remains unknown. |