Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CTSL1 |
| Gene Name: | CTSL1 |
| Protein Full Name: | Cathepsin L1 |
| Alias: | Major excreted protein |
| Mass (Da): | 37564 |
| Number AA: | 333 |
| UniProt ID: | P07711 |
| Locus ID: | 1514 |
| COSMIC ID: | CTSL1 |
| Gene location on chromosome: | 9q21.33 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.38 |
| Normal role description: | CTSL1 is a lysosomal cysteine proteinase and plays a major role in intracellular protein catabolism, with substrates such as collagen, elastin, and α-1 protease inhibitor. It has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia. It is important for homeostasis of the epidermis; regulation of the hair cycle and keratinocyte proliferation. It is over-expressed in a number of human cancers. |