Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PFN1 |
| Gene Name: | PFN1 |
| Protein Full Name: | Profilin-1 |
| Alias: | PRO1; PROF1; Profilin I |
| Mass (Da): | 15054 |
| Number AA: | 140 |
| UniProt ID: | P07737 |
| Locus ID: | 5216 |
| COSMIC ID: | PFN1 |
| Gene location on chromosome: | 17p13.3 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.07 |
| Commentary on involvement of protein in cancer: | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. |