Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CTSB |
| Gene Name: | CTSB |
| Protein Full Name: | Cathepsin B |
| Alias: | Amyloid precursor secretase; APP secretase; APPS; CATB; Cathepsin B1; CPSB; Cysteine protease; EC 3.4.22.1; Preprocathepsin B |
| Mass (Da): | 37822 |
| Number AA: | 339 |
| UniProt ID: | P07858 |
| Locus ID: | 1508 |
| COSMIC ID: | CTSB |
| Gene location on chromosome: | 8p23.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.22 |
| Normal role description: | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumour invasion and metastasis. This is mediated through abnormal localization of the protein to the cellular membrane or extracellular matrix and subsequent degredation of ECM components; this can potentially allow for easier tumour growth. |