Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Lyn |
| Gene Name: | LYN |
| Protein Full Name: | Tyrosine-protein kinase Lyn |
| Alias: | EC 2.7.10.2; JTK8; Kinase Lyn; LYN; V-yes-1 Yamaguchi sarcoma viral related oncogene |
| Mass (Da): | 58574 |
| Number AA: | 512 |
| UniProt ID: | P07948 |
| Locus ID: | 4067 |
| COSMIC ID: | LYN |
| Gene location on chromosome: | 8q12.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20259 |
| Percent of cancer specimens with mutations: | 0.48 |
| Normal role description: | LYN is a protein-tyrosine kinase. It is involved in regulation of innate and adaptive immune response, cell degranulation and hematopoiesis. It is also involved in signal transduction induced by growth factors, cytokines and integrin signalling. It also responds to DNA damage and genotoxic agents. Its regulations many aspects of the cell depending on cell type and context. Lyn has been associated with increase in invasiveness and mestasis of breast cancer cells. |