Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Hck |
| Gene Name: | HCK |
| Protein Full Name: | Tyrosine-protein kinase HCK |
| Alias: | B-cell,myeloid kinase; B-cell/myeloid kinase; BMK; EC 2.7.10.2; Hemopoietic cell kinase; JTK9; Kinase Hck; P56-HCK and P60-HCK; P59-Hck; P59-HCK/p60-HCK; P60-Hck |
| Mass (Da): | 59600 |
| Number AA: | 526 |
| UniProt ID: | P08631 |
| Locus ID: | 3055 |
| COSMIC ID: | HCK |
| Gene location on chromosome: | 20q11.21 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20288 |
| Percent of cancer specimens with mutations: | 0.83 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | HCK is a non-receptor protein tyrosine kinase of the Src subfamily found in hematopoietic cells, particularly of the myeloid and B-lymphoid lineages, that interacts with cell surface receptors such as Fc receptors and certain cytokine receptors. It plays important roles in the regulation of the innate immune responses including leukocyte function, phagocytosis, survival and proliferation, cell adhesion and migration. It promotes the reorganization of the actin cytoskeleton and actin polymerization, as well as the formation of podosomes. HCK is also involved in the release of inflammatory molecules from the cell, and can inhibit TP73-mediated apoptosis. Abberant activation of HCK by the BCR-ABL protein promotes cancer cell proliferation. A D399G mutation was associated with an ovarian mucinous carcinoma sample. |