Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | VIM |
| Gene Name: | VIM |
| Protein Full Name: | Vimentin |
| Alias: | VIME |
| Mass (Da): | 53652 |
| Number AA: | 466 |
| UniProt ID: | P08670 |
| Locus ID: | 7431 |
| COSMIC ID: | VIM |
| Gene location on chromosome: | 10p13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19780 |
| Percent of cancer specimens with mutations: | 0.6 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | VIM is a class-III intermediate filament found in non-epithelial cells such as mesenchymal-derived cells. It plays a role in maintaining cell shape, integrity of the cytoplasm, cytoskeleton stability, adhesion, migration, and signalling. It may be secreted by macrophages into the extracellular space upon stimulation by inflammatory molecules such as TNF-alpha. Its role in cancer is unknown. |