Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PAEP |
| Gene Name: | PAEP |
| Protein Full Name: | Glycodelin |
| Alias: | Placental protein 14;Pregnancy-associated endometrial alpha-2 globulin;Progestagen-associated endometrial protein;Progesterone-associated endometrial protein |
| Mass (Da): | 20624 |
| Number AA: | 180 |
| UniProt ID: | P09466 |
| Locus ID: | 5047 |
| COSMIC ID: | PAEP |
| Gene location on chromosome: | 9q34.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19603 |
| Percent of cancer specimens with mutations: | 0.14 |
| Normal role description: | PAEP is a secreted glycoprotein which has roles in sexual reproduction from fertilization all the way to maintenance of the uterine environment during pregnancy. In males, PAEP is secreted into the seminal fluid and will bind the sperm head to increase the overall half-life of sperm through suppression of the immune system and prevent premature capacitation. In females, PAEP will maintain the endometrium lining through inhibition of metalloproteinases. PAEP also has a role in promoting angiogenesis through activation of VEGF receptor expression. PAEP expression has correlated with ovarian and breast cancer development. PAEP may promote cancer through promoting angiogenesis and immunosuppression. |