Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PDGFRB |
| Gene Name: | PDGFRB |
| Protein Full Name: | Beta-type platelet-derived growth factor receptor |
| Alias: | CD140b; EC 2.7.10.1; JTK12; Kinase PDGFR-beta; PDGFR; PDGFR1; PDGFRb; PDGFR-beta; PDGF-R-beta; PGFRB; Platelet-derived growth factor receptor, beta polypeptide |
| Mass (Da): | 123968 |
| Number AA: | 1106 |
| UniProt ID: | P09619 |
| Locus ID: | 5159 |
| COSMIC ID: | PDGFRB |
| Gene location on chromosome: | 5q31-q32 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20891 |
| Percent of cancer specimens with mutations: | 1.16 |
| Deregulated in translocations: | Fusion partners include Tel, H4, Hip1, Cev4, and Rab5. |
| Normal role description: | PDGFRB is a receptor-tyrosine kinase that is activated upon binding platelet-derived growth factor (PDGF). |