Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CTSH |
| Gene Name: | CTSH |
| Protein Full Name: | Cathepsin H |
| Mass (Da): | 37394 |
| Number AA: | 335 |
| UniProt ID: | P09668 |
| Locus ID: | 1512 |
| COSMIC ID: | CTSH |
| Gene location on chromosome: | 15q25.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.26 |
| Normal role description: | CTSH is a cysteine protease. Important for degradation of proteins in lysosomes. It also has a role in cleaving C5 in the complement pathway, processing hydrophobic surfactant-associtated protein C, and transformation of LDL in monocytes-derived foam cells. In cancer, could be involved in degrading extracellular matrix and facilitate metastasis. |