Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | COX6C |
| Gene Name: | COX6C |
| Protein Full Name: | Cytochrome c oxidase subunit 6C |
| Alias: | Cytochrome c oxidase polypeptide VIc; Cytochrome c oxidase subunit VIc; EC 1.9.3.1 |
| Mass (Da): | 8781 |
| Number AA: | 75 |
| UniProt ID: | P09669 |
| Locus ID: | 1345 |
| COSMIC ID: | COX6C |
| Gene location on chromosome: | 8q22.2 |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.08 |
| Deregulated in translocations: | HMGA2 HMGA2 exon 3 was found fused to COX6C exon 2 in one case without cytogenetic analysis; HMGA2 (previously named HMGIC), sitting in 12q15, is the most frequently involved gene in uterine leiomyoma. |
| Normal role description: | Mitochondrial respiratory chain protein.This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. It is know to be upregulated in prostate cancer. |