Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PARP1 |
| Gene Name: | PARP1 |
| Protein Full Name: | Poly [ADP-ribose] polymerase 1 |
| Alias: | ADP-ribosyltransferase 1; ADPRT; ADPRT1; PADPRT-1; PARP; PARP-1; Poly (ADP-ribose) pol; Poly (ADP-ribose) polymerase 1; Poly[ADP-ribose] synthetase 1; PPOL |
| Mass (Da): | 113084 |
| Number AA: | 1014 |
| UniProt ID: | P09874 |
| Locus ID: | 142 |
| COSMIC ID: | PARP1 |
| Gene location on chromosome: | 1q41-q42 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20392 |
| Percent of cancer specimens with mutations: | 0.88 |
| Normal role description: | PARP1 plays a role in DNA repair; specifically in base excision repair (BER). During BER, PARP1 catalyzes the poly(ADP-ribosyl)ation of certain acceptor proteins involved in chromatin architecture and in DNA metabolism. Mutations in this gene have been found in mouth and ovarian tumors. |
| Commentary on involvement of protein in cancer: | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. |