Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FURIN |
| Gene Name: | FURIN |
| Protein Full Name: | Furin |
| Alias: | Dibasic-processing enzyme; FUR; Furin (paired basic amino acid cleaving enzyme); PACE; Paired basic amino acid residue cleaving enzyme; PCSK3; SPC1 |
| Mass (Da): | 86659 |
| Number AA: | 794 |
| UniProt ID: | P09958 |
| Locus ID: | 5045 |
| COSMIC ID: | FURIN |
| Gene location on chromosome: | 15q26.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.7 |
| Normal role description: | Furin is a pro-protein convertase responsible for processing precursor proteins into their biologically active products. It is a Ca2+-dependent serine endoprotease with substrates including pro-parathyroid hormone, transforming growth factor beta 1 precursor, pro-albumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, and von Willebrand factor, and it may also be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. FURIN is thought to play a role in tumour progression. |
| Commentary on involvement of protein in cancer: | 1/185 breast cancer-, 3/469 CNS-, and 2/145 lung cancer samples were also mutated (Sanger COSMIC) |