Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TFPT |
| Gene Name: | TFPT |
| Protein Full Name: | TCF3 fusion partner |
| Alias: | Amida; Amida, partner of the E2A; FB1; INO80 complex subunit F; INO80F; Protein FB1; TCF3 (E2A) fusion partner (in childhood Leukemia) |
| Mass (Da): | 28278 |
| Number AA: | 253 |
| UniProt ID: | P0C1Z6 |
| Locus ID: | 29844 |
| COSMIC ID: | TFPT |
| Gene location on chromosome: | 19q13.4 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.19 |
| Deregulated in translocations: | Childhood pre-B-cell acute lymphoblastic leukemia (4%), Inversion Event observed with E2A/TCF3, no protein product was observed, may not be a translocation. |
| Normal role description: | TFPT is a regulatory protein found to promote apoptosis and cause cell cycle arrest TFPT could promote apoptosis through activation of caspase 9 and p53 while directly interacting Cdc2/CDK1 to inhibit mitosis. TFPT function is regulated by accessory factors including Arc and Par-4. The TFPT gene locus can participate in an inversion event with TCF3 was has been implicated in pre-B-cell acute lymphoblastic leukemia. No observable protein product could be detected and thus may result in a deletion of TFPT. TFPT may function as a tumour suppressor protein in cancer. |