Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GLI2 |
| Gene Name: | GLI2 |
| Protein Full Name: | Zinc finger protein GLI2 |
| Alias: | GLI-kruppel family member GLI2; Oncogene GLI2; Tax helper protein; Tax helper protein 2; Tax-responsive element-2 holding; Tax-responsive element-25-bp sequence binding protein; THP; THP2 |
| Mass (Da): | 167783 |
| Number AA: | 1586 |
| UniProt ID: | P10070 |
| Locus ID: | 2736 |
| COSMIC ID: | GLI2 |
| Gene location on chromosome: | 2q14 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20061 |
| Percent of cancer specimens with mutations: | 1.7 |
| Normal role description: | GLI2 acts as a transcription factor that positively regulates the transcription of proto-oncogenes: Myc, cylin D and cyclin E, via the Sonic Hedgehog (Shh) pathway. GLI2 is implicated as a oncogene in the formation of embryonal carcinomas. |
| Commentary on involvement of protein in cancer: | Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Implicated in the transduction of SHH signal. |