Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GLI3 |
| Gene Name: | GLI3 |
| Protein Full Name: | Zinc finger protein GLI3 |
| Alias: | ACLS; DNA-binding protein; GCPS; GLI family zinc finger 3; GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome); Oncogene GLI3; PAPA; PAP-A; PAPA1; PAPB; PHS; PPDIV |
| Mass (Da): | 169863 |
| Number AA: | 1580 |
| UniProt ID: | P10071 |
| Locus ID: | 2737 |
| COSMIC ID: | GLI3 |
| Gene location on chromosome: | 7p14.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20306 |
| Percent of cancer specimens with mutations: | 2.63 |
| Normal role description: | Transcription factor in the sonic-hedgehog pathway and is normally involved in limb development but gene is also expressed in normal adult tissue throughout the body. GLI3 has different isoforms which can activate or repress different genes. Implicated in many congenital syndromes but role in oncogenesis no well established |