Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZSCAN22 |
| Gene Name: | ZSCAN22 |
| Protein Full Name: | Zinc finger and SCAN domain-containing protein 22 |
| Alias: | Krueppel-related zinc finger protein 2; Oncogene HKR2; Zinc finger and SCAN domain containing 22; Zinc finger and scan domain-containing protein 22; Zinc finger protein 50; Zinc finger protein 50;Krueppel-related zinc finger protein 2;Protein HKR2; ZNF50; ZSC22 |
| Mass (Da): | 54561 |
| Number AA: | 491 |
| UniProt ID: | P10073 |
| Locus ID: | 342945 |
| COSMIC ID: | ZSCAN22 |
| Gene location on chromosome: | 19q13.43 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.4 |
| Normal role description: | ZSCAN22 is a nuclear DNA-binding protein implicated in transcriptional regulation. It undergoes phosphorylation in response to DNA damage, probably by ATM or ATR. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). |
| Commentary on involvement of protein in cancer: | Only 1 mis-sense mutation identified in a pancreatic cancer in Sanger COSMIC |