Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PYY |
| Gene Name: | PYY |
| Protein Full Name: | Peptide YY |
| Alias: | PYY-I;Peptide tyrosine tyrosine;PYY-II |
| Mass (Da): | 11046 |
| Number AA: | 97 |
| UniProt ID: | P10082 |
| Locus ID: | 5697 |
| COSMIC ID: | PYY |
| Gene location on chromosome: | 17q21.1; 17q21.31 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.09 |
| Normal role description: | PYY is secreted peptide involved in inhibition of pancreatic secretions, gastric secretions and food uptake by gut epithelium. PYY is also thought to act on the hypothalamus to signal satiety. Loss of PYY expression has been observed in colon, pancreatic and breast cancer. PYY is thought to exert these effects by reducing intracellular cAMP levels to inhibit PKA mediated cell proliferation and growth. |