Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Myb |
| Gene Name: | MYB |
| Protein Full Name: | Transcriptional activator Myb |
| Alias: | C-myb; v-myb myeloblastosis viral oncogene |
| Mass (Da): | 72341 |
| Number AA: | 640 |
| UniProt ID: | P10242; Q708E2; Q14025; Q708E1; Q708E5; Q708E6; Q708E8; Q708E9; Q5THS6; Q708J0; Q70AC3; Q5THS4; Q5THS5 |
| Locus ID: | 4602 |
| COSMIC ID: | MYB |
| Gene location on chromosome: | 6q23.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19994 |
| Percent of cancer specimens with mutations: | 0.52 |
| Found in amplified chromosomal regions in human cancers: | Breast cancer harboring BRCA1 mutations (29%) |
| Deregulated in translocations: | Acute myeloid leukaemia, fusion partner is MYST3. T-cell acute lymphoblastic leukaemia, fusion partner is T-cell receptor beta(TCRbeta). Other known fusion parnters; TCRB, NFIB, MNX1. |
| Normal role description: | MYB is a site-specific transcriptional activator which has a role in regulating hematopoietic cell proliferation and differentiation. MYB is a homology to the viral-Myb oncogene found in avian retroviruses. Overexpression of MYB is implicated in various cancers. MYB predominantly functions as a transcription activator and constitutive activation or amplification may contribute to MYB-dependent malignancies. The MYB locus may also participate in a translocation event to create oncogenic fusion proteins implicated the development of J232leukemias. |