Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ARAF |
| Gene Name: | ARAF |
| Protein Full Name: | Serine/threonine-protein kinase A-Raf |
| Alias: | ARAF; A-RAF; ARAF1; A-raf-1; EC 2.7.11.1; Kinase A-Raf; PKS; PKS2; Proto-oncogene Pks; Raf; V-raf murine sarcoma 3611 viral oncogene |
| Mass (Da): | 67585 |
| Number AA: | 606 |
| UniProt ID: | A6NIT1; P10398; B4DMG5; Q5H9B2; Q96II5 |
| Locus ID: | 369 |
| COSMIC ID: | ARAF |
| Gene location on chromosome: | Xp11.23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 1531 |
| Percent of cancer specimens with mutations: | 0.4572175049 |
| Normal role description: | ARAF is a protein-serine/threonine kinase. It plays a role in Ras signalling pathway and found to interact phosphorylate with MEK1/2. Thus it is involved in cellular development and proliferation signals. Mutations in ARAF in cancer is rare but in cases where activations mutations are successful, it could play a play role in dysregulation of growth and proliferation signals contributing to cancer progression. |