Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CHGA |
| Gene Name: | CHGA |
| Protein Full Name: | Chromogranin-A |
| Alias: | Pituitary secretaory protein I; SP-I |
| Mass (Da): | 50688 |
| Number AA: | 457 |
| UniProt ID: | P10645 |
| Locus ID: | 1113 |
| COSMIC ID: | CHGA |
| Gene location on chromosome: | 14q32 |
| Number of cancer specimens: | 20363 |
| Percent of cancer specimens with mutations: | 0.37 |
| Commentary on involvement of protein in cancer: | The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.Pancreastatin strongly inhibits glucose induced insulin release from the pancreas. |