Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HSPA5 |
| Gene Name: | HSPA5 |
| Protein Full Name: | 78 kDa glucose-regulated protein |
| Alias: | BiP; Endoplasmic reticulum lumenal Ca; Glucose-regulated protein; GRP 78; GRP78; Heat shock 70kDa protein 5; Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD); Immunoglobulin heavy chain binding protein; MIF2 |
| Mass (Da): | 72333 |
| Number AA: | 654 |
| UniProt ID: | P11021 |
| Locus ID: | 3309 |
| COSMIC ID: | HSPA5 |
| Gene location on chromosome: | 9q33.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.33 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | HSPA5 is a heat shock protein that plays a role in multimeric protein assembly in the endoplasmic reticulum. It has been suggested that it also plays a role in monitoring protein transport through the cell due to its association with many ER proteins. HSPA5 may also have a role in recognizing misfolded proteins and targets them for proteasome-dependent degradation. In cultured cells, it appears that the protein protects cancer cells against ER stress-induced apoptosis. Its expression has been noted to be significantly higher in a variety of cancer tissues. |