Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAP2 |
| Gene Name: | MAP2 |
| Protein Full Name: | Microtubule-associated protein |
| Mass (Da): | 58954 |
| Number AA: | 559 |
| UniProt ID: | P11137 |
| Locus ID: | 4133 |
| COSMIC ID: | MAP2 |
| Gene location on chromosome: | 2q34-q35 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19809 |
| Percent of cancer specimens with mutations: | 2.26 |
| Normal role description: | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. This protein contains many different isoforms. Disregulation of MAP2 demonstrated in many neuronal diseases but pathophysiology unclear. Disruption in MAP2 function may prevent cell cycle progression through de-stabilzation of the centromere complex. |