Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RALB |
| Gene Name: | RALB |
| Protein Full Name: | Ras-related protein Ral-B |
| Alias: | GTP binding protein; RAS-like protein B; V-ral simian leukemia viral oncogene B, ras related |
| Mass (Da): | 23409 |
| Number AA: | 206 |
| UniProt ID: | P11234; Q53T32; Q6ZS74 |
| Locus ID: | 5899 |
| COSMIC ID: | RALB |
| Gene location on chromosome: | 2q14.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20338 |
| Percent of cancer specimens with mutations: | 0.25 |
| Normal role description: | RALB is a G protein involved in regulation of cell proliferation, cell migration, gene expression, membrane trafficking, stabilization and assembly of exocyst complex, cytokinesis, and abscission of sister chromatid during mitosis. It also as a role in inhbition of apoptosis. It is overexpressed in cancers and associated with cancer metastasis by promoting invasion. |