Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TOP2A |
| Gene Name: | TOP2A |
| Protein Full Name: | DNA topoisomerase 2-alpha |
| Alias: | Alpha isozyme; DNA topoisomerase II; DNA topoisomerase II alpha; DNA topoisomerase II-alpha; P11388-1; TOP2; TOP-2; Topoisomerase (DNA) II alpha 170kDa; TP2A |
| Mass (Da): | 174385 |
| Number AA: | 1531 |
| UniProt ID: | P11388 |
| Locus ID: | 7153 |
| COSMIC ID: | TOP2A |
| Gene location on chromosome: | 17q21.2 |
| Cancer protein type: | ?TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19777 |
| Percent of cancer specimens with mutations: | 0.97 |
| Normal role description: | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. This gene is the target of a variety of anti-cancer drugs and mutations of this gene may confer drug resistence. |