Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IGF2R |
| Gene Name: | IGF2R |
| Protein Full Name: | Cation-independent mannose-6-phosphate receptor |
| Alias: | 300 kDa mannose 6-phosphate receptor; Cation-independent mannose-6 phosphate receptor; Cation-independent mannose-6-phosphate receptor; CD222; CI Man-6-P receptor; CIMPR; CI-MPR; Insulin-like growth factor 2 receptor; M6P-R; MPR 300; MPR1; MPR300; MPRI |
| Mass (Da): | 274276 |
| Number AA: | 2491 |
| UniProt ID: | P11717 |
| Locus ID: | 3482 |
| COSMIC ID: | IGF2R |
| Gene location on chromosome: | 6q25-q27 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | TSP |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19706 |
| Percent of cancer specimens with mutations: | 1.84 |
| Normal role description: | Receptor for insulin-like growth factor-2. Also a receptor for mannose 6-phosphate. It is involved in many functions including lysosomal enzyme trafficking, activation of TGFb, fetal organogenesis, cytotoxic T cell induced apoptosis and IGF2 degradation. Reduced expression is seen in cancers and prevents production of TGFb degradation of IGF2 to inhibit cell growth. |