Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TPR |
| Gene Name: | TPR |
| Protein Full Name: | Nucleoprotein TPR |
| Alias: | Nucleoprotein TPR; Translocated promoter region; Translocated promoter region (to activated MET oncogene) |
| Mass (Da): | 267293 |
| Number AA: | 2363 |
| UniProt ID: | P12270; Q15624 |
| Locus ID: | 7175 |
| COSMIC ID: | TPR |
| Gene location on chromosome: | 1q25* |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 1.67 |
| Deregulated in translocations: | Translocation --> TPR-MET in gastric cancer; and TRK-T1 (TPR-NTRK1) in thyroid papillary carcinoma |
| Normal role description: | TPR is a coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes, and interacts directly with several components of the complex. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of the gene with several different kinase genes have been observed in some neoplasias such as thyroid papillary carcinoma and gastric cancer. |
| Commentary on involvement of protein in cancer: | 1/45 CNS tumour samples was also mutated. Only 1 liver-, 2 ovarian, and 2 bladder tumour samples were included in Sanger COSMIC. *Note: Chromosome location = 1q31.1 according to OMIM |