Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Src |
| Gene Name: | SRC |
| Protein Full Name: | Proto-oncogene tyrosine-protein kinase Src |
| Alias: | C-Src; EC 2.7.10.2; P60-SRC; P60-Src; SRC1 |
| Mass (Da): | 59704 |
| Number AA: | 536 |
| UniProt ID: | P12931 |
| Locus ID: | 6714 |
| COSMIC ID: | SRC |
| Gene location on chromosome: | 20q11.23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 22400 |
| Percent of cancer specimens with mutations: | 0.4 |
| Commonly recorded point mutations: | Q531• (11) |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | Rous sarcoma virus - Chicken |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | SRC is a non-receptor tyrosine kinase activated by many different classes of receptors including receptor tyrosine kinases, cytokine receptors and G-protein coupled receptors. It is involved in many signalling pathways controlling gene transcription, cell adhesion, cell cycle progression, apoptosis, migration, angiogenesis, and transformation. It is able to activate other protein tyrosine kinases. Src kinase activity has been shown to increase in several tumour tissues and cell lines. It is rarely mutated in primary tumors, but a trunacted, activated mutation has been described in several samples of advanced colorectal cancer. |