Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | XRCC6 |
| Gene Name: | XRCC6 |
| Protein Full Name: | X-ray repair cross-complementing protein 6 |
| Alias: | 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC75; CTCBF; D22S671; D22S731; G22P1; Ku autoantigen, 70kDa; KU70; Lupus Ku autoantigen protein p70; ML8; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6 |
| Mass (Da): | 69843 |
| Number AA: | 609 |
| UniProt ID: | P12956 |
| Locus ID: | 2547 |
| COSMIC ID: | XRCC6 |
| Gene location on chromosome: | 22q13.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20358 |
| Percent of cancer specimens with mutations: | 0.45 |
| Normal role description: | Repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition and V(D)J recombination. |