Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LYL1 |
| Gene Name: | LYL1 |
| Protein Full Name: | Protein lyl-1 |
| Alias: | Class A basic helix-loop-helix protein 18;Lymphoblastic leukemia-derived sequence 1 |
| Mass (Da): | 29938 |
| Number AA: | 280 |
| UniProt ID: | P12980 |
| Locus ID: | 4066 |
| COSMIC ID: | LYL1 |
| Gene location on chromosome: | 19p13.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.13 |
| Deregulated in translocations: | t(7;19)(q35;p13) --> TCRB/LYL1 in T-cell acute lymphoblastic leukemia |
| Normal role description: | Involved in hematopoeic differentiation. Demonstrated interaction with E2A and NF-kB. May function as OG by sequestring E2A which is itself a TSP. LYL1 overexpression has been demonstrated in immature lymphblasts and T-cell leukemias |