Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IFI30 |
| Gene Name: | IFI30 |
| Protein Full Name: | Gamma-interferon-inducible lysosomal thiol reducta |
| Alias: | Gamma-interferon-inducible lysosomal thiol reductase; Gamma-interferon-inducible protein IP-30; GILT; IFI-30; Interferon gamma-inducible protein 30 preproprotein; Interferon, gamma-inducible protein 30; IP30; MGC32056 |
| Mass (Da): | 29150 |
| Number AA: | 261 |
| UniProt ID: | P13284 |
| Locus ID: | 10437 |
| COSMIC ID: | IFI30 |
| Gene location on chromosome: | 19p13.11 |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.12 |
| Normal role description: | Metabolic enzyme. Thiol reductase. Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T cells or crosspresentation. Expressed constitutively in antigen-presenting cells and induced by IFN-gamma in other cell types. |