Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LCP1 |
| Gene Name: | LCP1 |
| Protein Full Name: | Plastin-2 |
| Alias: | CP64; LC64P; LCP-1; LPL; L-PLASTIN; L-plastin; Lymphocyte cytosolic protein 1; Plastin, L; Plastin-2; PLS2; PLSL |
| Mass (Da): | 70289 |
| Number AA: | 627 |
| UniProt ID: | P13796 |
| Locus ID: | 3936 |
| COSMIC ID: | LCP1 |
| Gene location on chromosome: | 13q14 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20262 |
| Percent of cancer specimens with mutations: | 0.6 |
| Deregulated in translocations: | BCL6 |
| Normal role description: | LCP1 is an actin binding protein that plays a role in activation of T cells by costimulation through TCR/CD3 and CD2 or CD28. It is also involved in cell surface expression of IL2Ra/CD25 and CD69. In non hodgkin follicular and burkitt lymphomas, a translocation induces swapping of promoters with BCL6. |