Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MIF |
| Gene Name: | MIF |
| Protein Full Name: | Macrophage migration inhibitory factor |
| Alias: | GIF; GLIF; Glycosylation-inhibiting factor; MMIF; Phenylpyruvate tautomerase |
| Mass (Da): | 12476 |
| Number AA: | 115 |
| UniProt ID: | P14174 |
| Locus ID: | 4282 |
| COSMIC ID: | MIF |
| Gene location on chromosome: | 22q11.23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.04 |
| Normal role description: | MIF is a pro-inflammatory cytokine that is involved in cell mediated immunity; in this capacity it counteracts the anti-inflammatory activity of glucocorticoids. MIF upregulation has been found in brain, colon, liver, lung, prostate, and skin tumors, with expression level negatively correlating with prognosis. |