Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HGF |
| Gene Name: | HGF |
| Protein Full Name: | Hepatocyte growth factor |
| Alias: | Hepatopoeitin-A;Scatter factor |
| Mass (Da): | 83134 |
| Number AA: | 728 |
| UniProt ID: | P14210 |
| Locus ID: | 3082 |
| COSMIC ID: | HGF |
| Gene location on chromosome: | 7p15.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19673 |
| Percent of cancer specimens with mutations: | 1.38 |
| Normal role description: | HGF binds to MET receptor tyrosine kinase and implicated in most developmental processes and throughout adulthood; HGF stimulates cell proliferation, survival, motility, and morphogenesis. MET receptor signalling is upregulated in a wide variety of tumour systems and clearly associated with oncogenesis through RTK pathways. |