Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PLA2G2A |
| Gene Name: | PLA2G2A |
| Protein Full Name: | Phospholipase A2, membrane associated |
| Alias: | GIIC sPLA2;Group IIA phospholipase A2;Non-pancreatic secretory phospholipase A2;Phosphatidylcholine 2-acylhydrolase 2A |
| Mass (Da): | 16083 |
| Number AA: | 144 |
| UniProt ID: | P14555 |
| Locus ID: | 5320 |
| COSMIC ID: | PLA2G2A |
| Gene location on chromosome: | 1p36.13 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.12 |
| Normal role description: | This phospholipase participates in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Expression positively correlates with prognosis in gastric, colorectal, and pancreatic cancer. Similarly, downregulation in prostate cancer has been observed. |