Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IDO1 |
| Gene Name: | IDO1 |
| Protein Full Name: | Indoleamine 2,3-dioxygenase 1 |
| Alias: | Indoleamine-pyrrole 2,3-dioxygenase |
| Mass (Da): | 45326 |
| Number AA: | 403 |
| UniProt ID: | P14902 |
| Locus ID: | 3620 |
| COSMIC ID: | IDO1 |
| Gene location on chromosome: | 8p11.22 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.47 |
| Normal role description: | Metabolic enzyme. Tryptophan degradation. Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Tryptophan depletion has an antiproliferative effect on T cells. Products of the IDO1 mediated tryptophan metabolism include kynurenine and other kynurenine-pathway products, that induce apoptosis in thymocytes and Th1 T cells. Highly expressed in many human cancers. |
| Commentary on involvement of protein in cancer: | No mutations reported on the Atlas of Genetics in Oncology and only one mutated sample on the SANGER COSMIC database. |