Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ETS1 |
| Gene Name: | ETS1 |
| Protein Full Name: | Protein C-ets-1 |
| Alias: | Avian erythroblastosis virus E26 (v-ets) oncogene-1; C-ets-1 protein; Ets protein; Ets1; ETS-1; ETS1A; EWSR2; FLJ10768; P54; V-ets erythroblastosis virus E26 oncogene 1 |
| Mass (Da): | 50408 |
| Number AA: | 441 |
| UniProt ID: | P14921 |
| Locus ID: | 2113 |
| COSMIC ID: | ETS1 |
| Gene location on chromosome: | 11q24.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20423 |
| Percent of cancer specimens with mutations: | 0.58 |
| Transduced into viral genome: | Avian erythroblastosis virus E26 (v-ets) |
| Normal role description: | Activates and represses many genes involved in early embryogenesis. Homologs also activated by growth factor signalling which leads to transcription of various gene targets. Mediated via CRE-binding domains. Plays a role in angiogenesis. Expression levels upregulated in many human cancers and correlates with poor prognosis |