Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GSPT1 |
| Gene Name: | GSPT1 |
| Protein Full Name: | Eukaryotic peptide chain release factor GTP-bindin |
| Alias: | ERF3a; ETF3A; G1 to S phase transition protein 1; G1 to S phase transition protein 1 homologue; GST1; GST1-HS; GTP-binding protein |
| Mass (Da): | 55756 |
| Number AA: | 499 |
| UniProt ID: | P15170 |
| Locus ID: | 2935 |
| COSMIC ID: | GSPT1 |
| Gene location on chromosome: | 16p13.13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19696 |
| Percent of cancer specimens with mutations: | 0.34 |
| Normal role description: | Protein synthesis protein. Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also involved in binding inhibitors of apoptosis (IAP) and faciliting apoptosis. |