Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | VAV1 |
| Gene Name: | VAV1 |
| Protein Full Name: | Proto-oncogene vav |
| Alias: | VAV; vav 1 guanine nucleotide exchange factor; Vav proto-oncogene |
| Mass (Da): | 98314 |
| Number AA: | 845 |
| UniProt ID: | P15498 |
| Locus ID: | 7409 |
| COSMIC ID: | VAV1 |
| Gene location on chromosome: | 19p13.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20427 |
| Percent of cancer specimens with mutations: | 1.21 |
| Normal role description: | Member of the Dbl family of GEFs. Plays an important role in hematopoiesis, in T-cell and B-cell development and activation. Functions in various signalling cascades. Acts as GEF for Rac1, Rac2 and RhoG. Its activity is regulated by tyrosine phosphorylation. Interaction with Nef proteins from HIV-1 leads to increased VAV activity. Implictaed in neuroblastoma and pancreatic tumours. |