Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ELN |
| Gene Name: | ELN |
| Protein Full Name: | Elastin |
| Alias: | Tropoelastin |
| Mass (Da): | 68499 |
| Number AA: | 786 |
| UniProt ID: | P15502 |
| Locus ID: | 2006 |
| COSMIC ID: | ELN |
| Gene location on chromosome: | 7q11.23 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19772 |
| Percent of cancer specimens with mutations: | 0.8 |
| Normal role description: | Elastin is a major structural protein along with fibrillin which composes the extracellular elastic fiber matrix found in blood vessels, lung, skin and other elastic tissues. Elastin is composed primarily of hydrophobic amino acids, glycine, valine, alanine, and proline and is crosslinked through lysine residues to form the elastic fiber matrix. Elastin has a role in regulating smooth muscle proliferation in the development of new blood vessels. Elastin's role in cancer development has not been well studied but is speculated to be involved in promoting angiogenesis to support tumour growth. |