Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AREG |
| Gene Name: | AREG |
| Protein Full Name: | Amphiregulin |
| Alias: | AR; Colorectum cell-derived growth factor; CRDGF; Schwannoma-derived growth factor; SDGF |
| Mass (Da): | 27895 |
| Number AA: | 252 |
| UniProt ID: | P15514 |
| Locus ID: | 374 |
| COSMIC ID: | AREG |
| Gene location on chromosome: | 4q13.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20057 |
| Percent of cancer specimens with mutations: | 0.09 |
| Normal role description: | AREG is a growth factor involved in proliferation of astrocytes, schwann cells and fibroblasts. AREG a member of the epiderminal growth factor (EGF) family and thus will bind EGF receptors leading to activation of mitogen activated pathways including MAPK. Being a mitogen overexpression of AREG can lead to a multitude of cancers. Activation of AREG can be mediated by activation of TNF-alpha converting enzyme or metalloproteinases which processes AREG to a mature form. Due to AREG's role in promoting cellular growth dysfunction of AREG has been implicated in cancer development. Overexpression has been implicated in colon, breast, liver, prostate, panreas, lung, squamous cell carcinoma, bladder, ovary, skin and myeloma cancers. |