Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NQO1 |
| Gene Name: | NQO1 |
| Protein Full Name: | NAD(P)H dehydrogenase [quinone] 1 |
| Alias: | Azoreductase;DT-diaphorase;Menadione reductase;NAD(P)H:quinone oxidoreductase 1;Phylloquinone reductase;Quinone reductase 1 |
| Mass (Da): | 30868 |
| Number AA: | 274 |
| UniProt ID: | P15559 |
| Locus ID: | 1728 |
| COSMIC ID: | NQO1 |
| Gene location on chromosome: | 16q22.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.18 |
| Deregulated in translocations: | Two polymorphisms have been characterized. The NQO1 *2 allele represents a C609T change in the cDNA coding for a Pro187Ser change in the enzyme. The NQO1 *3 allele is a C465T change in the cDNA coding for an Arg139Trp change. The NQO1 * 2 allele is much m |
| Normal role description: | Functions as a scavenger of free radicals in the NADPH cycle. Also potentially associates with p53. NQO1*2 allele has decreased catalytic activity and this SNP results in higher incidence of cancer. This is likely on the basis of greater suceptibility to free radical damage and loss of repair/apoptosis mechanisms. |