Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TCF3 |
| Gene Name: | TCF3 |
| Protein Full Name: | TCF3 protein |
| Alias: | Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription factor 3; Transcription factor E2-alpha; Transcription factor ITF-1 |
| Mass (Da): | 68491 |
| Number AA: | 658 |
| UniProt ID: | P15923 |
| Locus ID: | 6929 |
| COSMIC ID: | TCF3 |
| Gene location on chromosome: | 19p13.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20715 |
| Percent of cancer specimens with mutations: | 0.48 |
| Deregulated in translocations: | PBX1; TFPT; ZNF384 |
| Normal role description: | TCF3 is a transcriptional regulator of B cells. It is important for B cell hematopoiesis. Translocation events that deregulate its activities lead to leukemia. |