Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RPA2 |
| Gene Name: | RPA2 |
| Protein Full Name: | Replication protein A 32 kDa subunit |
| Alias: | REPA2; Replication factor-A protein 2; Replication protein A2; Replication protein A2, 32kDa; RF-A; RP-A; RPA32 |
| Mass (Da): | 29247 |
| Number AA: | 270 |
| UniProt ID: | P15927 |
| Locus ID: | 6118 |
| COSMIC ID: | RPA2 |
| Gene location on chromosome: | 1p35.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.12 |
| Normal role description: | RPA2 function as a DNA-damage repair protein. It is essential for DNA recombination, repair, and replication. RPA2's function is mediated by binding single-stranded DNA binding and protein interactions. RPA2 is also required for effective recruitment of the RAD51 -- a DNA double-strand break repair factor -- to chromatin in response to DNA damage, thereby implicating RPA2 as a possible tumour suppressor; however, upregulation of this gene has been found in breast, colon, and laryngeal tumors. |