Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TIMP2 |
| Gene Name: | TIMP2 |
| Protein Full Name: | Metalloproteinase inhibitor 2 |
| Alias: | CSC-21K;Tissue inhibitor of metalloproteinases 2 |
| Mass (Da): | 24399 |
| Number AA: | 220 |
| UniProt ID: | P16035 |
| Locus ID: | 7077 |
| COSMIC ID: | TIMP2 |
| Gene location on chromosome: | 17q25 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19538 |
| Percent of cancer specimens with mutations: | 0.22 |
| Normal role description: | TIMP2 is a protease inhibitor. It is known to complex with metalloproteinases (such as collagenases) and thereby irreversibly inactivate them by binding to their catalytic zinc cofactor. TIMP2 acts on: MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. It also functions as an inhibitor of angiogenesis. Allelic deletion of this gene are found in a third of breast tumors. |