Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ALOX15 |
| Gene Name: | ALOX15 |
| Protein Full Name: | Arachidonate 15-lipoxygenase |
| Alias: | 15-LOX; 15-LOX-1; Arachidonate omega-6 lipoxygenase; EC 1.13.11.31; EC 1.13.11.33; LOG15; LOX15; LX12L |
| Mass (Da): | 74673 |
| Number AA: | 662 |
| UniProt ID: | P16050 |
| Locus ID: | 246 |
| COSMIC ID: | ALOX15 |
| Gene location on chromosome: | 17p13.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.54 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | ALOX15 is a metabolic enzyme that converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid during leukotriene biosynthesis in response to inflammation. It is localized to the cytoplasm and the nucleus. It has been implicated in prostate, colorectal and breast cancers via dysregulation of expression (both high and low expressions have been seen in cancers), but observations have been controversial. While some researchers claim it has a mitogenic role through upregulation of EGF and ERK signalling pathways, others claim it has pro-apoptotic roles. |